Antibióticos

Description
Blasticidin S is a peptidyl nucleoside antibiotic isolated from Streptomyces griseochromogenes.
It specifically inhibits protein synthesis in both prokaryotes and eukaryotes by interfering with the peptide bound formation in the ribosomal machinery. Resistance to blasticidin is conferred by the blasticidin resistance gene from Bacillus cereus (bsr) which codes for blasticidin deaminase. Typically, bacteria are sensitive to blasticidin concentrations of 25-100 µg/ml, and mammalian cells to 1-10 µg/ml.

Formula: C17H26N8O5, 1 HCl
Molecular weight: 458.5
CAS Number : 2079-00-7

Contents
Blasticidin is provided as a colorless solution at 10 mg/ml. Blasticidin is shipped at room temperature and should be stored at -20°C. Blasticidin is stable up to 1 year when stored at -20°C.

Product Qty Cat. code
Blasticidin S (solution) 100 mg ant-bl-1
Blasticidin S (solution) 500 mg (25 x 2 ml) ant-bl-5
Blasticidin S (solution) 500 mg (50 ml bottle) ant-bl-5b
Blasticidin S (solution) 1 g ant-bl-10p


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Description
Hygromycin B is an aminoglycoside antibiotic produced by Streptomyces hygroscopicus. It inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome. Hygromycin B is effective on most bacteria, fungi and higher eukaryotes. Resistance to hygromycin is conferred by the hph gene from E. coli. Hygromycin B is normally used at a concentration of 50-200 µg/ml in mammalian cells and 100 µg/ml in bacteria.

Two grades of Hygromycin B are available:

  • Hygromycin B (purity >85%)
  • HygroGold™ (purity >98%)

Formula: C20H37N3O13, HCl
Molecular weight: 527.52
CAS Number : 31282-04-9
Contents
Hygromycin B and HygroGold™ are provided as 100 mg/ml yellow solutions. HygroGold™ is also provided as a powder. Products are shipped at room temperature. Store at -20°C. Hygromycin B solutions are stable for at least one year when stored at -20°C.

Product Qty Cat. code
Hygromycin B 1 g (100 mg/ml) ant-hm-1
Hygromycin B 5 g (100 mg/ml) ant-hm-5
HygroGold 1 g (100 mg/ml) ant-hg-1
HygroGold 5 g (100 mg/ml) ant-hg-5
HygroGold 10 g (powder) ant-hg-10p


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Description
Phleomycin is a glycopeptide antibiotic of the bleomycin family, isolated from a mutant strain of Streptomyces verticillus. It binds and intercalates DNA thus destroying the integrity of the double helix. Phleomycin is active against most bacteria, filamentous fungi, yeast, plant and animal cells. Use of phleomycin is recommended for cells poorly sensitive to Zeocin™, i.e. filamentous fungi and some yeasts. Phleomycin resistance is conferred by the Sh ble gene from Streptoalloteichus hindustanus which encodes a protein that binds to phleomycin, inhibiting its DNA cleavage activity.
Typically, phleomycin is used at a concentration of 10 µg/ml for yeasts and 25-150 µg/ml for filamentous fungi.

Empirical formula: C55H85O21N20S2Cu-HCL
Molecular weight: 1525
CAS Number : 11006-33-0

Contents

Phleomycin is provided as a blue solution at 20 mg/ml or as a powder. Phleomycin is shipped at room temperature. Store the solution at -20°C and the powder at 4°C. Phleomycin is stable for at least 1 year when properly stored.

Product Qty Cat. code
Phleomycin 100 mg (20 mg/ml) ant-ph-1
Phleomycin 500 mg (20 mg/ml) ant-ph-5
Phleomycin 250 mg (powder) ant-ph-2p
Phleomycin 500 mg (powder) ant-ph-5p
Phleomycin 1 g (powder) ant-ph-10p


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Description
Puromycin is an aminonucleoside antibiotic produced by Streptomyces alboniger. It specifically inhibits peptidyl transfer on both prokaryotic and eukaryotic ribosomes. This antibiotic inhibits the growth of Gram positive bacteria and various animal and insect cells. Puromycin can also be used in some particular conditions for the selection of E. coli transformants. Resistance to puromycin is conferred by the Pac gene encoding a puromycin N-acetyl-transferase (PAC) that was found in a Streptomyces producer strain.
Animal cells are generally sensitive to concentrations from 1 to 10 µg/ml.

Formula: C22H29N7O5, 2HCl
Molecular weight: 471.51
CAS Number : 58-58-2

Contents
Puromycin hydrochloride is provided as a colorless solution at 10 mg/ml. Puromycin is shipped at room temperature and should be stored at -20°C. Puromycin is stable for one year when stored at -20°C.

Product Qty Cat. code
Puromycin 100 mg (10 mg/ml) ant-pr-1
Puromycin 500 mg (10 mg/ml) ant-pr-5


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Description
InvivoGen is the sole worldwide producer of Zeocin™, a copper-chelated glycopeptide antibiotic produced by Streptomyces CL990.

Zeocin™ causes cell death by intercalating into DNA and cleaving it. This antibiotic is effective on most aerobic cells and is therefore useful for selection in bacteria, eukaryotic microorganisms, plant and animal cells. Resistance to Zeocin™ is conferred by the Sh ble gene product which inactivates Zeocin™ by binding to the antibiotic.
Zeocin™ is used at a concentration of 50-300 µg/ml for selection in mammalian cells and 25 µg/ml for bacterial selection.

Empirical formula: C55H85O21N20S2Cu - HCl
Molecular weight: 1525

Contents
Zeocin™ is provided as a blue solution at 100 mg/ml. Zeocin™ is shipped at room temperature and upon receipt should be stored at -20°C. Zeocin™ is stable for at least 1 year at -20°C. 

Product Qty Cat. code
Zeocin 1 g ant-zn-1
Zeocin 5 g (25 x 2 ml) ant-zn-5
Zeocin 5 g (50 ml bottle) ant-zn-5b
Zeocin 1 g (powder) ant-zn-1p
Zeocin 5 g (powder) ant-zn-1p

 

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Description
G418 is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II.
Selection in mammalian cells is usually achieved in three to seven days with concentrations ranging from 400 to 1000 µg/ml. Cells that are dividing are affected sooner than those that are not.

Formula: C20H40N4O10. 2H2SO4
Molecular weight: 692.7
CAS Number : 108321-42-2

Contents
G418 is provided as a colorless solution at 100 mg/ml. G418 is shipped at room temperature and should be stored at -20°C. G418 is stable for at least 1 year when stored at -20°C.

G418 1g (100 mg/ml) ant-gn-1
G418 5g (100 mg/ml) ant-gn-5


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